Type de poste: 
CDD
Date de début: 
07/2017
Durée: 
2 years
Ville: 
Nice
Nom du contact: 
Arnaud Hubstenberger
Mail du contact: 
Arnaud.HUBSTENBERGER@unice.fr
Plateforme: 
Missions: 

A funded postdoctoral position is available in the Hubstenberger team at the Institute of Biology Valrose, Nice-France. Our team was founded in 2017 as part of the main fundamental research body in France, the CNRS (National Center for Scientific Research). 

During development, the gene expression network must be coordinated, adapted to a changing environment, and marked by cell lineage and past history. Our primary goal is to understand how ribonucleoproteins (RNP) phase transitions integrate developmental and environmental cues to control RNA fate.

Background. 
We and others have previously shown how ribonucleoproteins (RNPs) can exist under different states: soluble, liquid droplets, hydrogels, or solid pathological aggregates. Within cells, RNPs undergo phase transitions between these states in response to environmental and developmental cues. More recently we developed a method to purify endogenous RNP granules. This method has allowed us to uncover new conceptual frameworks for studying the multi-scale structure of RNP co-assemblies and their function in RNA fate coordination (Currently under review in Cell). 

Approach. 
We utilize single molecule imaging, transcriptomics, system biology analysis, and
synthetic biology to manipulate RNPs within the cell. We are focused on developing a broad
range of approaches to dissect and integrate how RNP phase transitions coordinate the fate
of thousands of RNAs.

Relevant publications:
1- Hubstenberger, A., Noble, S.L., Cameron, C., and Evans, T.C. (2013). Translation Repressors, an RNA Helicase, and Developmental Cues Control RNP Phase Transitions during Early Development. Dev Cell 27, 161-173.
2- Hubstenberger, A.*, Cameron, C., Noble, S.L., Keenan S., and Evans, T.C (2015). Modifiers of solid RNP granules control normal RNP dynamics and mRNA activity in early development. J Cell Biol 211(3), 703–16.
 

Connaissances: 

The candidate should have experience with transcriptomics, genomics and/or quantitative image analysis. Experimental skills in biochemistry and molecular biology would be useful.

Spécificités: 
Please send a CV and statement of research interests to: Arnaud Hubstenberger at Arnaud.HUBSTENBERGER@unice.fr
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