Titre du projet: 
Enhancing the CRISPRdb database and related services
Porteur: 
GAUTHERET Daniel
Mots clefs: 
CRISPR
CAS
Annotation
Genomics
Genotyping
Description: 
CRISPRs are genetic loci present in bacteria and archaea which, associated to cas genes, provide defense against foreign sequences. The CRISPR-Cas system is a highly successful biotechnology tool and CRISPR sequences are used in genotyping pathogenic bacteria. The CRISPR database and services developed at I2BC are leading international resources for CRISPR sequence analysis. These resources now need to be strengthened and new tools and services should be added to meet growing user demands. This proposal is a collaboration between a senior member of the initial CRISPRdb team, two labs with strong expertise in cas gene sequence analysis and bacterial genotyping, and three bioinformatics platforms providing engineering support. The project is divided in two parts. First we will improve the existing CRISPR tools in terms of database structure, search engines and interfaces and develop a standalone version of the CRISPR finding tool to support large scale analyzes. Second, we will incorporate new features: a Cas sequence database and analysis tool and a bacterial genotyping tool. Involving key players such as Institut Pasteur and the French Bioinformatics Institute (that will host the future web site) should provide a strong foundation to this new CRISPR-Cas resource and promotes its international status.
cea
cnrs
inra
inria
inserm
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