Microarray probe design application. It enables the design of specific probes of each gene in an entire genome, with an original approach. The use of specific microarray technology requires a very detailed attention for the design of specific probes spotted on the solid phase. These problems are far from being commonplace since they refer to complex physicochemical constraints. We propose a new approach to design oligonucleotides which combines good specificity with a potentially high sensitivity. This approach is original in the biological point of view as far as in the algorithmic point of view, and is particularly adapted when dealing with a complex target mixture (where it’s difficult to find specific sequences fo all genes).
Rimour, S., D. Hill, C. Militon, and P. Peyret (2005) GoArrays: highly dynamic and efficient microarray probe design. Bioinformatics (Oxford, England) 21:1094-1103.